p73 mutations are not detected in sporadic and hereditary breast cancer.

doi:10.1023/a:1006237031070

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Article

p73 mutations are not detected in sporadic and hereditary breast cancer.

Breast cancer research and treatment - 1 Nov 1999

Schwartz D I, Lindor N M, Walsh-Vockley C, Roche P C, Mai M, Smith D I, Liu W, Couch F J

Abstract excerpt

Recently, a novel tumor suppressor gene, p73, was isolated and mapped to chromosome 1p36, a region commonly associated with loss of heterozygosity in neuroblastoma and other human malignancies, including breast cancer. The p73 gene shares considerable homology with the common tumor suppressor gene p53, both in composition and function. This study examines the potential participation of p73 in the pathogenesis of...

Topics

Breast Neoplasms
Carcinoma, Ductal, Breast
DNA-Binding Proteins
Female
Genes, Tumor Suppressor
Genetic Testing
Humans
Mutation
Nuclear Proteins
Polymerase Chain Reaction
Sequence Analysis, DNA
Tumor Protein p73
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 10634515
DOI: 10.1023/a:1006237031070

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