Article
Lack of evidence for a polymorphism at codon 160 of human O6-alkylguanine-DNA alkyltransferase gene in normal tissue and cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 1999
Wu M H, Lohrbach K E, Olopade O I, Kokkinakis D M, Friedman H S, Dolan M E
Abstract excerpt
O6-benzylguanine (BG) is a potent, specific inactivator of the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which enhances sensitivity to nitrosoureas in cells and tumor-bearing animals. BG is presently undergoing clinical trials for development as an agent to enhance the therap...
Topics
- Animals
- Antineoplastic Agents
- Cattle
- Codon
- Drug Resistance, Neoplasm
- Drug Screening Assays, Antitumor
- Guanine
- Humans
- Mutation
- Neoplasms
- O(6)-Methylguanine-DNA Methyltransferase
- Polymerase Chain Reaction
- Polymorphism, Genetic