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Article

Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.

Carcinogenesis - 1 Dec 2004

Shinmura Kazuya, Tao Hong, Goto Masanori, Igarashi Hisaki, Taniguchi Terumi, Maekawa Masato, Takezaki Toshiro, Sugimura Haruhiko

Abstract excerpt

Oxidized DNA base lesions, such as thymine glycol (Tg) and 8-hydroxyguanine, are often toxic and mutagenic and have been implicated in carcinogenesis. To clarify whether NEIL1 protein, which exhibits excision repair activity towards such base lesions, is involved in gastric carcinogenesis, we examined 71 primary gastric cancers from Japanese patients and four gastric cancer cell lines for mutations and genetic...

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Source

Identifiers

PMID: 15319300
DOI: 10.1093/carcin/bgh267

Genes

NEIL1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Inactivating mutations of the human base excision repair gene NEIL1 in gastric cancer.PMID 15319300Read ↗

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