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Article

Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism.

Lung cancer (Amsterdam, Netherlands) - 1 Jun 2004

Yang Mihi, Coles Brian F, Caporaso Neil E, Choi Yunhee, Lang Nicholas P, Kadlubar Fred F

Abstract excerpt

The formation of DNA adducts is thought to be a critical step for the induction of chemically induced cancer. O(6)-Methylguanine-DNA methyltransferase (MGMT) is a ubiquitously expressed enzyme that repairs DNA adducts formed by alkylating carcinogens. Thus, genetic polymorphisms of the MGMT that could result in differences in MGMT activity are potential risk factors for cancer. In the present study, we...

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Source

Identifiers

PMID: 15140540
DOI: 10.1016/j.lungcan.2003.12.003

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Lack of association between Caucasian lung cancer risk and O6-methylguanine-DNA methyltransferase-codon 178 genetic polymorphism.PMID 15140540Read ↗

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