Creation of human alkyltransferases resistant to O6-benzylguanine.

Article

Creation of human alkyltransferases resistant to O6-benzylguanine.

Cancer research - 15 May 1997

Christians F C, Dawson B J, Coates M M, Loeb L A

Abstract excerpt

O6-benzylguanine (BG), an inhibitor of O6-alkylguanine-DNA alkyltransferase, is being tested clinically for its ability to chemosensitize tumors to alkylating agents. Although this drug may increase the killing of tumors that express high levels of alkyltransferase, it would also be expected to r...

Topics

Binding Sites
Carcinogens
Drug Resistance
Enzyme Inhibitors
Escherichia coli
Guanine
Humans
Methylnitronitrosoguanidine
Methyltransferases
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Transformation, Genetic

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