Article
Tumor-associated mutations in O⁶ -methylguanine DNA-methyltransferase (MGMT) reduce DNA repair functionality.
Molecular carcinogenesis - 1 Mar 2014
Lamb Kristy L, Liu Yanfeng, Ishiguro Kimiko, Kwon Youngho, Paquet Nicolas, Sartorelli Alan C, Sung Patrick, Rockwell Sara, Sweasy Joann B
Abstract excerpt
MGMT is the primary vehicle for cellular removal of alkyl lesions from the O-6 position of guanine and the O-4 position of thymine. While key to the maintenance of genomic integrity, MGMT also removes damage induced by alkylating chemotherapies, inhibiting the efficacy of cancer treatment. Germline variants of human MGMT are well-characterized, but somatic variants found in tumors were, prior to this work,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.