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Article

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.

Mutation research - 15 May 1996

Crone T M, Goodtzova K, Pegg A E

Abstract excerpt

Amino acid residues in the human O6-alkylguanine-DNA alkyltransferase (AGT) were mutated and seventeen of the mutant proteins expressed in the ada- ogt-E. coli strain GWR 109 which is very sensitive to killing by methylating agents because of the absence of endogenous alkyltransferases. Thirteen...

Topics

Amino Acid Sequence
Base Sequence
DNA Repair
Dose-Response Relationship, Drug
Escherichia coli
Humans
Methylnitronitrosoguanidine
Methyltransferases
Molecular Sequence Data
Mutagens
Mutation
O(6)-Methylguanine-DNA Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Recombinant Proteins

Structure-Activity Relationship

Source

Identifiers

PMID: 8632775
DOI: 10.1016/0921-8777(95)00058-5

Genes

AGT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8632775-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.PMID 8632775Read ↗

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