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Article

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

Cancer research - 1 Dec 1994

Crone T M, Goodtzova K, Edara S, Pegg A E

Abstract excerpt

O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve as a substrate for the AGT forming S-benzylcysteine at the cysteine acceptor site. The effects of a number of mutations...

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Identifiers

PMID: 7954470

Genes

AGT

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.PMID 7954470Read ↗

Amino acid residues affecting the activity and stability of human O6-alkylguanine-DNA alkyltransferase.Semantic proximity Read ↗

Interaction of mammalian O(6)-alkylguanine-DNA alkyltransferases with O(6)-benzylguanine.Semantic proximity Read ↗

Mutations in the Ada O6-alkylguanine-DNA alkyltransferase conferring sensitivity to inactivation by O6-benzylguanine and 2,4-diamino-6-benzyloxy-5-nitrosopyrimidine.Semantic proximity Read ↗

The role of tyrosine-158 in O6-alkylguanine-DNA alkyltransferase activity.Semantic proximity Read ↗

Protection of CHO cells by mutant forms of O6-alkylguanine-DNA alkyltransferase from killing by 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) plus O6-benzylguanine or O6-benzyl-8-oxoguanine.Semantic proximity Read ↗

Genetic chemoprotection with mutant O6-alkylguanine-DNA-alkyltransferases.Semantic proximity Read ↗

Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents.Semantic proximity Read ↗

Modulation of ethylnitrosourea-induced toxicity and mutagenicity in human cells by O6-benzylguanine.Semantic proximity Read ↗

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Degradation of the alkylated form of the DNA repair protein, O(6)-alkylguanine-DNA alkyltransferase.Semantic proximity Read ↗

Creation of human alkyltransferases resistant to O6-benzylguanine.Semantic proximity Read ↗

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