Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

Article

Mutations in human O6-alkylguanine-DNA alkyltransferase imparting resistance to O6-benzylguanine.

Cancer research - 1 Dec 1994

Crone T M, Goodtzova K, Edara S, Pegg A E

Abstract excerpt

O6-Benzylguanine is an inactivator of O6-alkylguanine-DNA alkyltransferases (AGT) which is currently entering clinical trials as an agent improving the cancer chemotherapeutic activity of chloroethylnitrosoureas and other alkylating agents. O6-Benzylguanine acts by virtue of its ability to serve...

Topics

Amino Acid Sequence
Base Sequence
Binding Sites
DNA
Drug Resistance
Guanine
Humans
Methyltransferases
Molecular Sequence Data
Mutation
O(6)-Methylguanine-DNA Methyltransferase
Structure-Activity Relationship

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