Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo.

doi:10.1097/00008571-199812000-00012

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Article

Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo.

Pharmacogenetics - 1 Dec 1998

Rothen J P, Haefeli W E, Meyer U A, Todesco L, Wenk M

Abstract excerpt

Slow acetylators of the polymorphic N-acetyltransferase 2 (NAT2, EC 2.3.1.5) suffer more often from side-effects of NAT-substrates than fast acetylators. Since concomitant administration of drugs may inhibit NAT2, we studied the influence of acetaminophen on NAT2 in human hepatic cytosol in vitro...

Topics

Acetaminophen
Acetylation
Arylamine N-Acetyltransferase
Enzyme Inhibitors
Genotype
Humans
Liver
Phenotype

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