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Article

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation.

Drug metabolism and disposition: the biological fate of chemicals - 1 Dec 2025

Lanphier Raeanne M, Latham Bethany D, Gerringer Amanda J, Interrante Tyler, Jones Corbin D, De Buysscher Tristan, Fallon John K, Jackson Klarissa D

Abstract excerpt

Sulfamethoxazole (SMX) is associated with idiosyncratic drug-induced liver injury, which remains difficult to predict. SMX is metabolized by N-acetyltransferases (NAT1/NAT2) to form N4-acetyl sulfamethoxazole (NA-SMX), and by cytochrome P450-mediated oxidation to form SMX-hydroxylamine. This study aimed to characterize SMX metabolism in vitro and investigate how NAT1 and NAT2 variation influences NA-SMX...

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Share to Acetylation
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41344065
DOI: 10.1016/j.dmd.2025.100195
PMCID: PMC12861138

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 17 Oct 2026.

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