Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amantadine acetylation may be effected by acetyltransferases other than NAT1 or NAT2.

Canadian journal of physiology and pharmacology - 1 Jan 2000

Bras A P, Hoff H R, Aoki F Y, Sitar D S

Abstract excerpt

Amantadine is a drug with a primary amino group, and consequently a likely candidate for metabolism by acetylation. This study assessed the possibility that a person's polymorphic (NAT2) acetylator phenotype could be used to predict the extent of amantadine acetylation. Thirty-eight normal, healthy volunteers were NAT2 acetylator phenotyped with sulfapyridine. Of the six fastest (75-86%) and six slowest (34-40%)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Acetylation
Share to Acetyltransferases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Amantadine

Share to Arylamine N-Acetyltransferase

Share to In Vitro Techniques

Share to Isoenzymes

Share to Sex Factors

Source

Identifiers

PMID: 10030449
DOI: 10.1139/cjpp-76-7-8-701

Genes

NAT2
NAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amantadine acetylation may be effected by acetyltransferases other than NAT1 or NAT2.PMID 10030449Read ↗

N-acetyltransferases: pharmacogenetics and clinical consequences of polymorphic drug metabolism.Semantic proximity Read ↗

N-acetyltransferase (NAT) 1 and NAT2 enzyme activities drive interindividual variability in sulfamethoxazole N-acetylation.Semantic proximity Read ↗

Mesalazine pharmacokinetics and NAT2 phenotype.Semantic proximity Read ↗

Arylamine N-acetyltransferase acetylation polymorphisms: paradigm for pharmacogenomic-guided therapy- a focused review.Semantic proximity Read ↗

Acetylator status, drug metabolism and disease.Semantic proximity Read ↗

Acetaminophen is an inhibitor of hepatic N-acetyltransferase 2 in vitro and in vivo.Semantic proximity Read ↗

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.Semantic proximity Read ↗

Pharmacogenetics, Regulation and Structural Properties of the Drugmetabolizing Enzymes Arylamine N-acetyltransferases.Semantic proximity Read ↗

Aminopyrine metabolism in man: the acetylation of aminoantipyrine cosegregates with acetylation of caffeine.Semantic proximity Read ↗

N-acetylation phenotyping with sulphadimidine in a Turkish population.Semantic proximity Read ↗

Genotype-Guided Hydralazine TherapySemantic proximity Read ↗

Influence of polymorphic N-acetyltransferases on non-malignant spontaneous disorders and on response to drugs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.