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Article

Phenotyping of N-acetyltransferase type 2 by caffeine from uncontrolled dietary exposure.

European journal of clinical pharmacology - 1 Mar 2004

Jetter Alexander, Kinzig-Schippers Martina, Illauer Michael, Hermann Robert, Erb Katharina, Borlak Jürgen, Wolf Helga, Smith Gillian, Cascorbi Ingolf, Sörgel Fritz, Fuhr Uwe

Abstract excerpt

BACKGROUND AND OBJECTIVE: The standard approach for phenotyping of the human arylamine N-acetyltransferase 2 (NAT2) uses urinary caffeine metabolite ratios after a caffeine test dose taken in after methylxanthine abstinence. We tested whether these standardization measures were still needed when a more sensitive quantification technique was used. METHODS: A new liquid chromatography/tandem mass spectrometry...

Topics

Acetylation
Administration, Oral
Adult
Arylamine N-Acetyltransferase
Caffeine
Chromatography, High Pressure Liquid
Diet
Female
Genotype
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Phenotype

Spectrometry, Mass, Electrospray Ionization

Time Factors

Uracil

Uric Acid

Xanthines

Source

Identifiers

PMID: 14747882
DOI: 10.1007/s00228-003-0718-8

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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