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Article

Unexpected Acetylation of Endogenous Aliphatic Amines by Arylamine N-Acetyltransferase NAT2.

Angewandte Chemie (International ed. in English) - 17 Aug 2020

Conway Louis P, Rendo Veronica, Correia Mário S P, Bergdahl Ingvar A, Sjöblom Tobias, Globisch Daniel

Abstract excerpt

N-Acetyltransferases play critical roles in the deactivation and clearance of xenobiotics, including clinical drugs. NAT2 has been classified as an arylamine N-acetyltransferase that mainly converts aromatic amines, hydroxylamines, and hydrazines. Herein, we demonstrate that the human arylamine N-acetyltransferase NAT2 also acetylates aliphatic endogenous amines. Metabolomic analysis and chemical synthesis...

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Identifiers

PMID: 32497306
DOI: 10.1002/anie.202005915
PMCID: PMC7497018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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