Article
Mouse models in tumor suppression.
Oncogene - 24 Dec 1998
Ghebranious N, Donehower L A
Abstract excerpt
Genetic lesions found in tumors are often targeted to the negative growth regulatory tumor suppressor genes. Much of our understanding of tumor suppressor gene function is derived from experimental manipulations in cultured cells. Recently, however, the generation of mice with germ line tumor sup...
Topics
- Adenomatous Polyposis Coli Protein
- Animals
- BRCA1 Protein
- BRCA2 Protein
- Cyclin-Dependent Kinase Inhibitor p16
- Cytoskeletal Proteins
- DNA-Binding Proteins
- Disease Models, Animal
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Humans
- Ligases
- Membrane Proteins
- Mice
- Mice, Knockout
- Neoplasm Proteins
- Neoplasms
- Neurofibromin 1