Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

How Genetically Engineered Mouse Tumor Models Provide Insights Into Human Cancers

25 Jan 2011

Abstract excerpt

Genetically engineered mouse models (GEMMs) of human cancer were first created nearly 30 years ago. These early transgenic models demonstrated that mouse cells could be transformed in vivo by expression of an oncogene. A new field emerged, dedicated to generating and using mouse models of human cancer to address a wide variety of questions in cancer biology. The aim of this review is to highlight the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Cells and Metastasis
Share to Cancer Research and Treatments
Share to Virus-based gene therapy research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21263096
DOI: 10.1200/jco.2010.30.8304

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

How Genetically Engineered Mouse Tumor Models Provide Insights Into Human CancersPMID 21263096Read ↗

Mouse Models of CancerSemantic proximity Read ↗

Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial OutcomesSemantic proximity Read ↗

Genetically modified mouse models in cancer studies.Semantic proximity Read ↗

Cancer modeling in the modern era: progress and challenges.Semantic proximity Read ↗

Non-germline genetically engineered mouse models for translational cancer researchSemantic proximity Read ↗

Mouse models in oncogenesis and cancer therapySemantic proximity Read ↗

The right time, the right place: will targeting human cancer-associated mutations to the mouse provide the perfect preclinical model?Semantic proximity Read ↗

Genetically engineered mouse models for hereditary cancer syndromes.Semantic proximity Read ↗

The Use of Targeted Mouse Models for Preclinical Testing of Novel Cancer TherapeuticsSemantic proximity Read ↗

Genetically modified mice in cancer research.Semantic proximity Read ↗

Genetically Engineered Models Have Advantages over Xenografts for Preclinical StudiesSemantic proximity Read ↗

Harnessing preclinical mouse models to inform human clinical cancer trialsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.