Article
Animal models of tumor-suppressor genes.
Annual review of genetics - 1 Jan 2001
Hakem R, Mak T W
Abstract excerpt
The development of cancer requires multiple genetic alterations perturbing distinct cellular pathways. In human cancers, these alterations often arise owing to mutations in tumor-suppressor genes whose normal function is to either inhibit the proliferation, apoptosis, or differentiation of cells, or maintain their genomic integrity. Mouse models for tumor suppressors frequently provide definitive evidence for the...
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