Tumour suppressor gene mutations in humans and mice: parallels and contrasts.

doi:10.1093/emboj/17.23.6783

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Article

Tumour suppressor gene mutations in humans and mice: parallels and contrasts.

The EMBO journal - 1 Dec 1998

Hooper M L

Abstract excerpt

Tumour suppressor genes prevent cancer development. They can be identified by studying humans, but a full understanding of the mechanisms of their action requires the production of animal models. Mice with mutations in tumour suppressor genes can be produced by gene targeting. The phenotypic cons...

Topics

Animals
DNA-Binding Proteins
Genes, Retinoblastoma
Genes, Tumor Suppressor
Humans
Kidney Neoplasms
Mice
Mutation
Syndrome
Transcription Factors
WT1 Proteins
Wilms Tumor

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