Article
A Mouse Model System to Genetically Dissect the Molecular Mechanisms Regulating Tumorigenesis
15 Sept 2006
Abstract excerpt
The vast majority of human tumors are of epithelial origin and result from the accumulation of mutations that alter the function of pathways that control critical cellular processes, including proliferation, checkpoint regulation, and apoptosis. Authentically replicating these events in animal models is critical to understanding the biology of cancer and for testing the feasibility of novel therapies. We...
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