Article
Genetically modified mouse models in cancer studies.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico - 1 Dec 2008
Santos Javier, Fernández-Navarro Pablo, Villa-Morales María, González-Sánchez Laura, Fernández-Piqueras José
Abstract excerpt
Genetically modified animals represent a resource of immense potential for cancer research. Classically, genetic modifications in mice were obtained through selected breeding experiments or treatments with powerful carcinogens capable of inducing random mutagenesis. A new era began in the early 1980s when genetic modifications by inserting foreign DNA genes into the cells of an animal allowed for the development...
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