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Article

Transgenic mouse models for tumor suppressor genes.

Cancer detection and prevention - 1 Jan 1998

Palapattu G S, Bao S, Kumar T R, Matzuk M M

Abstract excerpt

The identification and cloning of tumor suppressor genes has mostly relied on familial human cancer predisposition syndromes and reverse genetics. Recent advances in manipulating the mouse genome by gene targeting techniques in embryonic stem (ES) cells has led to the generation of mutant mouse models mimicking many human syndromes. Mice lacking one or both alleles of known tumor suppressor genes have been...

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Identifiers

PMID: 9466053
DOI: 10.1046/j.1525-1500.1998.00012.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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