Article
Transgenic mouse models for tumor suppressor genes.
Cancer detection and prevention - 1 Jan 1998
Palapattu G S, Bao S, Kumar T R, Matzuk M M
Abstract excerpt
The identification and cloning of tumor suppressor genes has mostly relied on familial human cancer predisposition syndromes and reverse genetics. Recent advances in manipulating the mouse genome by gene targeting techniques in embryonic stem (ES) cells has led to the generation of mutant mouse m...
Topics
- Animals
- Disease Models, Animal
- Genes, Tumor Suppressor
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Neoplasms, Experimental