Tumor suppressor gene mutations in mice.

doi:10.1146/annurev.genet.30.1.603

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Article

Tumor suppressor gene mutations in mice.

Annual review of genetics - 1 Jan 1996

Jacks T

Abstract excerpt

Over the past several years, a number of human tumor suppressor genes have been cloned and characterized. Germline mutations in tumor suppressor genes strongly predispose to cancer, and they are also mutated somatically in sporadic forms of the disease. In order to create animal models for the fa...

Topics

Animals
Genes, Tumor Suppressor
Humans
Mice
Models, Biological
Mutation
Neoplasms, Experimental
Phenotype
Species Specificity

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