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Article

Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1995

Drake C G, Rozzo S J, Hirschfeld H F, Smarnworawong N P, Palmer E, Kotzin B L

Abstract excerpt

F1 progeny of New Zealand Black (NZB) and New Zealand White (NZW) mice spontaneously develop an autoimmune process remarkably similar to human systemic lupus erythematosus. Previous studies have implicated major genetic contributions from the NZW MHC and from a dominant NZB gene on chromosome 4. To identify additional NZB contributions to lupus-like disease, (NZB x SM/J)F1 x NZW backcross mice were followed for...

Topics

Animals
Crosses, Genetic
Disease Models, Animal
Female
Genes
Genotype
Humans
Hybridization, Genetic
Lupus Erythematosus, Systemic
Lupus Nephritis
Major Histocompatibility Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mice

Mice, Inbred NZB

Phenotype

Source

Identifiers

PMID: 7868910

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7868910-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Analysis of the New Zealand Black contribution to lupus-like renal disease. Multiple genes that operate in a threshold manner.PMID 7868910Read ↗

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