Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain.

doi:10.1002/art.10887

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Article

Enhanced susceptibility to end-organ disease in the lupus-facilitating NZW mouse strain.

Arthritis and rheumatism - 1 Apr 2003

Xie Chun, Zhou Xin J, Liu Xuebin, Mohan Chandra

Abstract excerpt

OBJECTIVE: Although the NZW mouse strain is phenotypically normal, fulminant lupus glomerulonephritis (GN) develops when NZW mice are bred to several other strains, such as NZB, BXSB, B6.Sle1, and B6.Yaa. Based on the observation that aging NZW mice exhibit histologic evidence of GN, we sought to test our hypothesis that NZW mice may be more susceptible to immune-mediated renal damage. METHODS: NZW mice, as well...

Topics

Animals
Anti-Glomerular Basement Membrane Disease
Blood Urea Nitrogen
Crosses, Genetic
Female
Genetic Predisposition to Disease
Immune Tolerance
Immunity, Innate
Kidney
Lupus Nephritis
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice

Mice, Inbred BALB C

Mutation

Proteinuria

Rabbits

Species Specificity

Survival Rate

Source

Open in PubMed

Identifiers

PMID: 12687552
DOI: 10.1002/art.10887

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