Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

doi:10.1073/pnas.91.9.4062

Article

Genetic analysis of the NZB contribution to lupus-like autoimmune disease in (NZB x NZW)F1 mice.

26 Apr 1994

Abstract excerpt

Lupus-like autoimmunity in (NZB x NZW)F1 mice is frequently marked by the development of a severe and fatal renal disease. Genes from both NZB and NZW parents are required for the full expression of disease. We applied a mapping technique based on polymorphism in simple sequence repeats to the analysis of (NZB x NZW)F1 x NZW backcross mice to determine the NZB genetic contribution to disease. The results show...

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