Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay.

doi:10.1242/jcs.112.4.559

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Article

Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay.

Journal of cell science - 1 Feb 1999

Liang D T, Hodson J A, Forsburg S L

Abstract excerpt

MCM proteins are a conserved family of eukaryotic replication factors implicated in the initiation of DNA replication and in the discrimination between replicated and unreplicated chromatin. However, most mcm mutants in yeast arrest the cell cycle after bulk DNA synthesis has occurred. We investi...

Topics

Alleles
Cell Cycle
Cell Cycle Proteins
Cell Division
DNA Replication
DNA-Binding Proteins
Fungal Proteins
Gene Dosage
Minichromosome Maintenance Complex Component 4
Minichromosome Maintenance Complex Component 6
Mutation
Phenotype
S Phase
Saccharomyces cerevisiae Proteins
Schizosaccharomyces
Schizosaccharomyces pombe Proteins
Temperature

Source

Open in PubMed

Identifiers

PMID: 9914167
DOI: 10.1242/jcs.112.4.559

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9914167-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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