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Article

Reduced dosage of a single fission yeast MCM protein causes genetic instability and S phase delay.

Journal of cell science - 1 Feb 1999

Liang D T, Hodson J A, Forsburg S L

Abstract excerpt

MCM proteins are a conserved family of eukaryotic replication factors implicated in the initiation of DNA replication and in the discrimination between replicated and unreplicated chromatin. However, most mcm mutants in yeast arrest the cell cycle after bulk DNA synthesis has occurred. We investigated the basis for this late S phase arrest by analyzing the effects of a temperature-sensitive mutation in fission...

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PMID: 9914167
DOI: 10.1242/jcs.112.4.559

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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