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Article

A role for the START gene-specific transcription factor complex in the inactivation of cyclin B and Cut2 destruction.

Molecular biology of the cell - 1 Oct 2000

Tournier S, Millar J B

Abstract excerpt

Hyperactivation of Cdc2 in fission yeast causes cells to undergo a lethal premature mitosis called mitotic catastrophe. This phenotype is observed in cdc2-3w wee1-50 cells at high temperature. Eleven of 17 mutants that suppress this phenotype define a single complementation group, mcs1. The mcs1-77 mutant also suppresses lethal inactivation of the Wee1 and Mik1 tyrosine kinases and thus delays mitosis...

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PMID: 11029045
DOI: 10.1091/mbc.11.10.3411
PMCID: PMC15003

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