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Article

Altered splenic B cell subset development in mice lacking phosphoinositide 3-kinase p85alpha.

International immunology - 1 Dec 2004

Donahue Amber C, Hess Kristen L, Ng Kwan L, Fruman David A

Abstract excerpt

The signaling enzyme phosphoinositide 3-kinase (PI3K) is activated following B cell receptor (BCR) engagement and by many other receptors on B lymphocytes. Mice lacking p85alpha, the predominant PI3K regulatory isoform, exhibit defects in B cell development and activation that are grossly similar...

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Source

Identifiers

PMID: 15520044
DOI: 10.1093/intimm/dxh180

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15520044-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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