Article
PI3K-signalling in B- and T-cells: insights from gene-targeted mice.
Biochemical Society transactions - 1 Feb 2003
Okkenhaug K, Vanhaesebroeck B
Abstract excerpt
Phosphoinositide 3-kinases (PI3Ks) are important signalling enzymes in most cell types. Recent gene targeting studies have shed light on the importance of this family of lipid kinases in the immune system, and the complex mechanisms by which these kinases are regulated in vivo. We have recently reported a phenotype of mice in which the p110 delta PI3K catalytic subunit was inactivated by point mutation. In the...
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