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Article

Btk dosage determines sensitivity to B cell antigen receptor cross-linking.

Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997

Satterthwaite A B, Cheroutre H, Khan W N, Sideras P, Witte O N

Abstract excerpt

Mutations in Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. Btk is a critical component of signaling pathways regulating B cell development and function. We used a genetic approach to determine whether Btk is also limiting for these processes. One allele of a murine Btk transgene expressed a dosage of Btk (25% of endogenous...

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Identifiers

PMID: 9371815
DOI: 10.1073/pnas.94.24.13152
PMCID: PMC24278

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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