Article
Btk dosage determines sensitivity to B cell antigen receptor cross-linking.
Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 1997
Satterthwaite A B, Cheroutre H, Khan W N, Sideras P, Witte O N
Abstract excerpt
Mutations in Btk result in the B cell immunodeficiencies X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency (xid) in mice. Btk is a critical component of signaling pathways regulating B cell development and function. We used a genetic approach to determine whether Btk is al...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Animals
- B-Lymphocytes
- Cell Line
- Cell Separation
- Flow Cytometry
- Gene Dosage
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Protein-Tyrosine Kinases
- Receptors, Antigen, B-Cell
- Transgenes