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Article

Role of Bruton's tyrosine kinase in B cell development.

Developmental immunology - 1 Jan 2001

Maas A, Hendriks R W

Abstract excerpt

X-linked agammaglobulinemia (XLA) is one of the most frequent inherited immunodeficiency diseases in man and is characterized by an almost complete arrest of B cell differentiation at the pre-B cell stage. The gene defective in XLA encodes the cytoplasmic signaling molecule Bruton's tyrosine kinase (Btk). Next to the CBA/N strain of mice, carrying a single amino acid substitution mutation in the Btk gene, which...

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Source

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Identifiers

PMID: 11785667
DOI: 10.1155/2001/28962
PMCID: PMC2276078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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