Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Defective B cell development and function in Btk-deficient mice.

Immunity - 1 Sept 1995

Khan W N, Alt F W, Gerstein R M, Malynn B A, Larsson I, Rathbun G, Davidson L, Müller S, Kantor A B, Herzenberg L A

Abstract excerpt

Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X-linked agammaglobulinemia (XLA), and to milder B cell activation deficiencies in murine X-linked immune deficiency (Xid). To elucidate unequivocally potential Btk functions in mice, we generated mutations in embryonic stem cells, which eliminated the ability to encode Btk pleckstrin...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to B-Lymphocytes
Share to Cell Line
Share to Flow Cytometry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Lymphocyte Activation

Share to Mice, Inbred C57BL

Share to Mutation

Share to Rabbits

Source

Identifiers

PMID: 7552994
DOI: 10.1016/1074-7613(95)90114-0

Genes

RAG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defective B cell development and function in Btk-deficient mice.PMID 7552994Read ↗

Role of Bruton's tyrosine kinase in B cell development.Semantic proximity Read ↗

Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage.Semantic proximity Read ↗

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective.Semantic proximity Read ↗

X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase.Semantic proximity Read ↗

Severe B cell deficiency in mice lacking the tec kinase family members Tec and Btk.Semantic proximity Read ↗

Btk dosage determines sensitivity to B cell antigen receptor cross-linking.Semantic proximity Read ↗

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.Semantic proximity Read ↗

Mutation of Unique Region of Bruton's Tyrosine Kinase in Immunodeficient XID MiceSemantic proximity Read ↗

Expression of Bruton's tyrosine kinase protein within the B cell lineageSemantic proximity Read ↗

Impaired B cell maturation in mice lacking Bruton's tyrosine kinase (Btk) and CD40.Semantic proximity Read ↗

Btk levels set the threshold for B-cell activation and negative selection of autoreactive B cells in miceSemantic proximity Read ↗

Deficiency of Bruton's tyrosine kinase in B cell precursor leukemia cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.