Article
Defective B cell development and function in Btk-deficient mice.
Immunity - 1 Sept 1995
Khan W N, Alt F W, Gerstein R M, Malynn B A, Larsson I, Rathbun G, Davidson L, Müller S, Kantor A B, Herzenberg L A
Abstract excerpt
Mutations in the Bruton's tyrosine kinase (Btk) gene have been linked to severe early B cell developmental blocks in human X-linked agammaglobulinemia (XLA), and to milder B cell activation deficiencies in murine X-linked immune deficiency (Xid). To elucidate unequivocally potential Btk functions in mice, we generated mutations in embryonic stem cells, which eliminated the ability to encode Btk pleckstrin...
Topics
- Agammaglobulinaemia Tyrosine Kinase
- Animals
- Antibody Formation
- B-Lymphocytes
- Cell Line
- Flow Cytometry
- Humans
- Immunoglobulins
- Lymphocyte Activation
- Male
- Mice