Article
Role of class IA phosphoinositide 3-kinase in B lymphocyte development and functions.
Biochemical Society transactions - 1 Apr 2004
Koyasu S
Abstract excerpt
PI3K (phosphoinositide 3-kinase) family members control a variety of cellular responses, such as cell growth, survival, cytoskeletal remodelling and the trafficking of intracellular organelles, in many cell types, including lymphocytes. It has been difficult to evaluate the roles of distinct PI3Ks in immune responses, because specific inhibitors for each PI3K are lacking and most stimuli activate multiple PI3Ks....
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