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Article

Intermediates in formation and activity of the RNA polymerase II preinitiation complex: holoenzyme recruitment and a postrecruitment role for the TATA box and TFIIB.

Genes & development - 1 Jan 1999

Ranish J A, Yudkovsky N, Hahn S

Abstract excerpt

Assembly and activity of yeast RNA polymerase II (Pol II) preinitiation complexes (PIC) was investigated with an immobilized promoter assay and extracts made from wild-type cells and from cells containing conditional mutations in components of the Pol II machinery. We describe the following findings: (1) In one step, TFIID and TFIIA assemble at the promoter independently of holoenzyme. In another step, holoenzyme...

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Identifiers

PMID: 9887099
DOI: 10.1101/gad.13.1.49
PMCID: PMC316368

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