Article
Downstream promoter interactions of TFIID TAFs facilitate transcription reinitiation.
Genes & development - 1 Nov 2017
Joo Yoo Jin, Ficarro Scott B, Soares Luis M, Chun Yujin, Marto Jarrod A, Buratowski Stephen
Abstract excerpt
TFIID binds promoter DNA to recruit RNA polymerase II and other basal factors for transcription. Although the TATA-binding protein (TBP) subunit of TFIID is necessary and sufficient for in vitro transcription, the TBP-associated factor (TAF) subunits recognize downstream promoter elements, act as coactivators, and interact with nucleosomes. In yeast nuclear extracts, transcription induces stable TAF binding to...
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