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Article

Distinct activated and non-activated RNA polymerase II complexes in yeast.

The EMBO journal - 2 Sept 1996

Akhtar A, Faye G, Bentley D L

Abstract excerpt

We used a transcriptional run-on assay in permeabilized yeast cells to study the distribution of RNA polymerase II (pol II) complexes before and after activation by Gal4. Polymerases were found engaged on the gene at the 5' end before activation, but only appeared at the 3' end after activation. Mutations of the pol II C-terminal domain (CTD), the CTD kinase Kin28 and the holoenzyme subunit Srb2 all inhibited the...

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PMID: 8887556
PMCID: PMC452197

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