Article
Two membrane-associated tyrosine phosphatase homologs potentiate C. elegans AKT-1/PKB signaling.
PLoS genetics - 1 Jul 2006
Hu Patrick J, Xu Jinling, Ruvkun Gary
Abstract excerpt
Akt/protein kinase B (PKB) functions in conserved signaling cascades that regulate growth and metabolism. In humans, Akt/PKB is dysregulated in diabetes and cancer; in Caenorhabditis elegans, Akt/PKB functions in an insulin-like signaling pathway to regulate larval development. To identify molecules that modulate C. elegans Akt/PKB signaling, we performed a genetic screen for enhancers of the akt-1 mutant...
Topics
- Amino Acid Sequence
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Membrane
- Gene Expression Regulation
- Genetic Techniques
- Molecular Sequence Data
- Mutation
- Phenotype
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Protein Structure, Tertiary
- Protein Tyrosine Phosphatases