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Article

The human tumour suppressor PTEN regulates longevity and dauer formation in Caenorhabditis elegans.

Oncogene - 6 Jan 2005

Solari Florence, Bourbon-Piffaut Angélique, Masse Ingrid, Payrastre Bernard, Chan Andrew M-L, Billaud Marc

Abstract excerpt

The PTEN tumour suppressor is a phosphatase that dephosphorylates phosphatidylinositol 3, 4, 5 triphosphate (PIP3) and protein substrates. PTEN function is modulated by its carboxy-terminal region, which contains several clustered phosphorylation sites and a PDZ-binding motif (PDZbm). Although PTEN growth suppression effect is well demonstrated, its additional biological roles are less well understood. DAF-18, a...

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Source

Identifiers

PMID: 15637588
DOI: 10.1038/sj.onc.1207978

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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