Article
Generation of a reporter-null allele of Ppap2b/Lpp3and its expression during embryogenesis.
The International journal of developmental biology - 1 Jan 2009
Escalante-Alcalde Diana, Morales Sara L, Stewart Colin L
Abstract excerpt
Our knowledge of how bioactive lipids participate during development has been limited principally due to the difficulties of working with lipids. The availability of some of these lipids is regulated by the Lipid phosphate phosphatases (LPPs). The targeted inactivation of Ppap2b, which codes for the isoenzyme Lpp3, has profound developmental defects. Lpp3 deficient embryos die around E9.5 due to extraembryonic...
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