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Article

Novel reporter alleles of GSK-3α and GSK-3β.

PloS one - 1 Jan 2012

Barrell William B, Szabo-Rogers Heather L, Liu Karen J

Abstract excerpt

Glycogen Synthase Kinase 3 (GSK-3) is a key player in development, physiology and disease. Because of this, GSK-3 inhibitors are increasingly being explored for a variety of applications. In addition most analyses focus on GSK-3β and overlook the closely related protein GSK-3α. Here, we describe novel GSK-3α and GSK-3β mouse alleles that allow us to visualise expression of their respective mRNAs by tracking...

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Identifiers

PMID: 23185619
DOI: 10.1371/journal.pone.0050422
PMCID: PMC3503927

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