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Article

Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.

PloS one - 1 Jan 2012

Runkel Fabian, Hintze Maik, Griesing Sebastian, Michels Marion, Blanck Birgit, Fukami Kiyoko, Guénet Jean-Louis, Franz Thomas

Abstract excerpt

BACKGROUND: Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one class. Studies with functional inactivation of Plcd isozyme encoding genes in mice have revealed that loss of both Plcd1 and Plcd3 causes early embryonic death....

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Source

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Identifiers

PMID: 22723964
DOI: 10.1371/journal.pone.0039203
PMCID: PMC3378570

Genes

PLCD3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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