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Article

Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997

Ji Q S, Winnier G E, Niswender K D, Horstman D, Wisdom R, Magnuson M A, Carpenter G

Abstract excerpt

The activation of many tyrosine kinases leads to the phosphorylation and activation of phospholipase C-gamma1 (PLC-gamma1). To examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 results in embryonic lethality at approximately embryonic day (E) 9.0. Histological analysis indicates that Plcg1 (-/-)...

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Identifiers

PMID: 9096335
DOI: 10.1073/pnas.94.7.2999
PMCID: PMC20311

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Source receipt: pubmed, retrieved 7 Sept 2026.

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