Article
Essential role of the tyrosine kinase substrate phospholipase C-gamma1 in mammalian growth and development.
Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 1997
Ji Q S, Winnier G E, Niswender K D, Horstman D, Wisdom R, Magnuson M A, Carpenter G
Abstract excerpt
The activation of many tyrosine kinases leads to the phosphorylation and activation of phospholipase C-gamma1 (PLC-gamma1). To examine the biological function of this protein, homologous recombination has been used to selectively disrupt the Plcg1 gene in mice. Homozygous disruption of Plcg1 resu...
Topics
- Animals
- Cells, Cultured
- Embryonic and Fetal Development
- Gene Targeting
- Genotype
- Heterozygote
- Isoenzymes
- Mice
- Phospholipase C gamma
- Protein-Tyrosine Kinases
- Signal Transduction
- Stem Cells
- Substrate Specificity
- Type C Phospholipases