Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.

doi:10.1124/mol.55.1.102

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Article

Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.

Molecular pharmacology - 1 Jan 1999

Forman S A, Zhou Q

Abstract excerpt

Ethanol enhances the gating of a family of related ligand-gated ion channels including nicotinic acetylcholine, serotonin type 3, gamma-aminobutyric acid-A, and glycine receptors. This common action may reflect shared molecular and kinetic mechanisms. In all of these receptors, ethanol enhances m...

Topics

Acetylcholine
Animals
Ethanol
Female
Ion Channels
Mutation
Receptors, Nicotinic
Xenopus

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