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Article

Novel modulation of a nicotinic receptor channel mutant reveals that the open state is stabilized by ethanol.

Molecular pharmacology - 1 Jan 1999

Forman S A, Zhou Q

Abstract excerpt

Ethanol enhances the gating of a family of related ligand-gated ion channels including nicotinic acetylcholine, serotonin type 3, gamma-aminobutyric acid-A, and glycine receptors. This common action may reflect shared molecular and kinetic mechanisms. In all of these receptors, ethanol enhances multichannel currents elicited with low agonist concentrations, but not with high agonist concentrations. A single...

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Identifiers

PMID: 9882703
DOI: 10.1124/mol.55.1.102

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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