Article
Ethanol enhances taurine-activated glycine receptor function.
Alcoholism, clinical and experimental research - 1 Sept 2010
Welsh Brian T, Kirson Dean, Allen Hunter M, Mihic S John
Abstract excerpt
BACKGROUND: Emerging evidence suggests that taurine acts as a partial agonist on glycine receptors (GlyR) in vitro and in vivo. Ethanol acts as an allosteric modulator on the GlyR producing a leftward shift of the glycine concentration-response curve, with no enhancing effects observed at saturating glycine concentrations. However, to date, no electrophysiological studies have been performed on ethanol modulation...
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