Article
Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
The Journal of pharmacology and experimental therapeutics - 1 Feb 2012
Borghese Cecilia M, Blednov Yuri A, Quan Yu, Iyer Sangeetha V, Xiong Wei, Mihic S John, Zhang Li, Lovinger David M, Trudell James R, Homanics Gregg E, Harris R Adron
Abstract excerpt
Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels. Ethanol potentiates glycine activation of the GlyR, and putative binding sites for alcohol are located in the transmembrane (TM) domains between and within subunits. To alter alcohol sensitivity of GlyR, we introduced two mutations in the GlyR α1 subunit, M287L (TM3) and Q266I (TM2). After expression in Xenopus laevis oocytes, both mutants showed...
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