Article
RAP1A GTP/GDP cycles determine the intracellular location of the late endocytic compartments and contribute to myogenic differentiation.
Experimental cell research - 10 Jan 1999
Pizon V, Méchali F, Baldacci G
Abstract excerpt
RAP1A protein is a small Ras-like GTPase that accumulates during muscle differentiation. In this study, we observed variable intracellular location of the endogenous RAP1A protein and concomitant relocation of the late endocytic compartments in differentiating myogenic cells. By monitoring the nu...
Topics
- Animals
- Biomarkers
- Cathepsin D
- Cell Differentiation
- Cell Fusion
- Cell Line
- Endosomes
- Fluorescent Antibody Technique, Indirect
- GTP-Binding Proteins
- Gene Expression Regulation
- Guanosine Diphosphate
- Guanosine Triphosphate
- Humans
- Lysosomes
- Mice
- Muscles
- Mutation
- Recombinant Fusion Proteins