Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.

doi:10.1038/sj.onc.1203984

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Article

Rap1A protein interferes with various MAP kinase activating pathways in skeletal myogenic cells.

Oncogene - 7 Dec 2000

Pizon V, Baldacci G

Abstract excerpt

Constitutive expression of the activated Rap1A protein inhibits differentiation of myogenic C2 cells whereas the inactivated Rap1A protein favours cell differentiation and induces late endocytic compartments clustering. Although the role of Rap1A in MAPK activation has been analysed in various cell types, the signalling pathways activated by Rap1A have not been explored in myogenic cells. In this study, we...

Topics

Androstadienes
Blood Proteins
Blotting, Western
Cell Division
Cell Line
Cyclic AMP
Down-Regulation
Enzyme Activation
Flavonoids
Guanosine Diphosphate
Guanosine Triphosphate
MAP Kinase Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MAP Kinase Signaling System

Mitogen-Activated Protein Kinase Kinases

Mitogen-Activated Protein Kinases

Muscle, Skeletal

Mutation

Phosphatidylinositol 3-Kinases

Source

Open in PubMed

Identifiers

PMID: 11146560
DOI: 10.1038/sj.onc.1203984

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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