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Article

Identification of a novel domain of Ras and Rap1 that directs their differential subcellular localizations.

The Journal of biological chemistry - 21 May 2004

Nomura Kazuhiro, Kanemura Hoshimi, Satoh Takaya, Kataoka Tohru

Abstract excerpt

The small GTPase Ha-Ras and Rap1A exhibit high mutual sequence homology and share various target proteins. However, they exert distinct biological functions and exhibit differential subcellular localizations; Rap1A is predominantly localized in the perinuclear region including the Golgi apparatus and endosomes, whereas Ha-Ras is predominantly localized in the plasma membrane. Here, we have identified a small...

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PMID: 15031297
DOI: 10.1074/jbc.M314169200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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