Article
Dynamics of the subcellular localization of RalBP1/RLIP through the cell cycle: the role of targeting signals and of protein-protein interactions.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 May 2012
Fillatre Jonathan, Delacour Delphine, Van Hove Lucie, Bagarre Thomas, Houssin Nathalie, Soulika Marina, Veitia Reiner A, Moreau Jacques
Abstract excerpt
The small G protein Ras regulates many cell processes, such as gene expression, proliferation, apoptosis, and cell differentiation. Its mutations are associated with one-third of all cancers. Ras functions are mediated, at least in part, by Ral proteins and their downstream effector the Ral-binding protein 1 (RalBP1). RalBP1 is involved in endocytosis and in regulating the dynamics of the actin cytoskeleton. It...
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