Article
A location, location, location mutation impairs DNM2-mediated release of nascent autophagosomes from recycling endosomes.
Autophagy - 1 Jul 2020
Puri Claudia, Rubinsztein David C
Abstract excerpt
Elucidation of the membranes contributing to autophagosomes has been a critical question in the field, and an area of active research. Recently, we showed that key events in autophagosome formation, from PtdIns3P formation/WIPI2 recruitment to LC3-GABARAP membrane conjugation, occur on the RAB11A-positive compartment (recycling endosomes). This observation raised the question of how the LC3-positive autophagosome...
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