Article
Rap2 function requires palmitoylation and recycling endosome localization.
Biochemical and biophysical research communications - 23 Jan 2009
Uechi Yukiko, Bayarjargal Maitsetseg, Umikawa Masato, Oshiro Minoru, Takei Kimiko, Yamashiro Yoshito, Asato Tsuyoshi, Endo Shogo, Misaki Ryo, Taguchi Tomohiko, Kariya Ken-ichi
Abstract excerpt
Rap2A, Rap2B, and Rap2C are Ras-like small G proteins. The role of their post-translational processing has not been investigated due to the lack of information on their downstream signaling. We have recently identified the Traf2- and Nck-interacting kinase (TNIK), a member of the STE20 group of mitogen-activated protein kinase kinase kinase kinases, as a specific Rap2 effector. Here we report that, in HEK293T...
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